C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/317, 260/241
C07D 487/04 (2006.01) C07D 207/34 (2006.01) C07D 209/70 (2006.01) C07D 313/08 (2006.01) C07D 491/04 (2006.01) C07D 491/044 (2006.01) C07D 495/04 (2006.01)
Patent
CA 1185971
ABSTRACT OF THE INVENTION Tricyclic derivatives of substituted pyrrole acids, e.g., substituted 4,10-dihydro-10-oxo-1H- [1]benzoxepino[4,3-b]pyrrole-2-acetic acids or the 5-thia analogs thereof have been prepared via hydrolysis of a precursor or decarboxylation of a precursor-diacid. These tricyclic compounds are found to have high analgesic and anti-inflammatory activities but low ulcerogenic side effects.
406141
Allison Debra L.
Doherty James B.
Dorn Conrad P.
Finke Paul E.
Shen Tsung-Ying
Goudreau Gage Dubuc
Merck & Co. Inc.
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