Tricyclic erythromycin derivatives

C - Chemistry – Metallurgy – 07 – H

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C07H 17/00 (2006.01) C07H 17/08 (2006.01) A61K 31/71 (1995.01)

Patent

CA 2277116

Compounds, or pharmaceutically acceptable salts and esters thereof, of formulas: (I); (II); (III); or (IV); wherein A, B, D and E, R1, R2, and Z specifically defined, having antibacterial activity, pharmaceutical compositions containing said compounds, treatment of bacterial infections with such compositions, and processes for the preparation of the compounds.

L'invention concerne des composés, ou bien leurs sels et esters pharmaceutiquement acceptables, ayant les formules (I), (II), (III), ou bien (IV) dans lesquelles A, B, D et E, R?1¿, R?2¿, et Z sont spécifiquement définis, et présentant une activité antibactérienne. L'invention concerne d'autre part des compositions pharmaceutiques contenant ces composés, le traitement d'infections bactériennes avec de telles compositions, ainsi que des procédés pour la préparation de ces composés.

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