Tricyclic farnesyl protein transferase inhibitors

Details Tricyclic farnesyl protein transferase inhibitors Tricyclic farnesyl protein transferase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/44 (2006.01) A61K 31/445 (2006.01) A61K 31/55 (2006.01) A61P 35/00 (2006.01) C07D 401/12 (2006.01) C07D 407/14 (2006.01) C07D 413/14 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2354779

Disclosed are compounds of formula (1.0) wherein R13 represents an imidazole ring; R14 represents a carbamate, urea, amide or sulfonamide group; R8 represents H when the alkyl chain between the amide group and the R13 imidazole group is substituted, or R8 represents a substituent such aa arylalkyl, heteroarylalkyl or cycloalkyl; and the remaining substituents are as defined herein. Also disclosed are compounds wherein R8 is H, and the alkyl chain between the amide group and the R13 imidazole group is unsubstituted. Also disclosed is a method of treating cancer and a method of inhibiting farnesyl protein transferase using the disclosed compounds.

L'invention concerne des composés de formule (1.0) dans laquelle R?13¿ représente un cycle imidazole; R?14¿ représente un carbamate, urée, amide ou un groupe sulfonamide; R?8¿ représente H lorsque la chaîne alkyle entre le groupe amide et le groupe imidazole R?13¿ est substituée ou R?8¿ représente un substituant, à savoir un arylalkyle, hétéroarylalkyle ou cycloalkyle; et les substituants restants sont tels que définis dans le descriptif. L'invention concerne aussi des composés dans lesquels R?8¿ désigne H et la chaîne alkyle entre le groupe amide et le groupe imidazole R?13¿ n'est pas substituée. L'invention concerne encore un procédé de traitement du cancer et un procédé d'inhibition de la farnésyl protéine transférase utilisant les composés faisant l'objet de cette invention.

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