C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/04 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) A61K 31/675 (2006.01) C07D 221/16 (2006.01) C07D 401/14 (2006.01) C07D 409/14 (2006.01) C07D 417/14 (2006.01) C07F 9/6558 (2006.01)
Patent
CA 2173963
A method of inhibiting Ras function and therefore inhibiting cellular growth is disclosed. The method comprises the administration of a compound containing a tricyclic ring system to a biological system. In particular, the method inhibits cellular growth in a mammal such as a human being. Novel compounds of formula (4.0) are disclosed. Also disclosed are processes for making 3-substituted compounds of formula (4.0). Further disclosed are novel compounds which are intermediates in the processes for making the 3-substituted compounds of formula (4.0).
Un procédé, qui permet d'inhiber la fonction Ras et donc la croissance cellulaire, consiste à administrer à un organisme biologique un composé contenant un système tricyclique. Ce procédé inhibe notamment la croissance cellulaire chez un mammifère tel que l'homme. On décrit de nouveaux composés de formule (4.0). On décrit aussi des procédés donnant des composés 3- substitués de formule (4.0). On décrit enfin de nouveaux composés qui constituent des intermédiaires pour les procédés donnant les composés précédents.
Bishop W. Robert
Doll Ronald J.
Mallams Alan K.
Njoroge F. George
Petrin Joanne M.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Schering Corporation
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