Trifluoromethyl substituted benzamides as kinase inhibitors

Details Trifluoromethyl substituted benzamides as kinase inhibitors Trifluoromethyl substituted benzamides as kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 217/02 (2006.01) A61K 31/428 (2006.01) A61K 31/472 (2006.01) A61P 35/00 (2006.01) C07D 237/30 (2006.01) C07D 239/74 (2006.01) C07D 239/84 (2006.01) C07D 277/62 (2006.01)

Patent

CA 2575316

The invention relates to trifluoromethyl substituted benzamide compounds of the formula (I), pharmaceuticals comprising these compounds, their use as or for the manufacture of phar~maceuticals, particularly as inhibitors of protein kinases and/or the treatment of a condition, disorder or disease state mediated by a protein kinase activity and/or a proliferative disease, methods of treatment comprising administering the compounds, especially of therapeutic and prophylactic treatment, methods for the manufacture of the compounds and novel intermediates and partial steps for their synthesis.

L~invention porte sur des composés benzamides substitués trifluorométhyle de la formule (I), des produits pharmaceutiques comprenant ces composés, leur utilisation comme ou pour la fabrication de produits phar­maceutiques, en particulier comme inhibiteurs de kinases de protéine et/ou pour le traitement d~une condition, d~un trouble ou d~une maladie résultant d~une activité kinase de protéine et/ou une maladie proliférative, des procédés de traitement comprenant l~administration des composés, surtout de traitement thérapeutique et prophylactique, des procédés de fabrication des composés et produits intermédiaires novateurs et des phases partielles pour leur synthèse.

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