A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/00 (2006.01) A61K 39/00 (2006.01) C07H 5/10 (2006.01) C07H 15/12 (2006.01) C07K 9/00 (2006.01)
Patent
CA 2324616
The present invention provides novel .alpha.-O-linked glycoconjugates such as .alpha.-O-linked glycopeptides, as well as convergent methods for synthesis thereof. The general preparative approach is exemplified by the synthesis of the mucin motif commonly found on epithelial tumor cell surfaces. The present invention further provides compositions and methods of treating cancer using the .alpha.-O-linked glycoconjugates.
La présente invention concerne de nouveaux glycoconjugués à liaison .alpha.-O tels que des glycopeptides à liaison .alpha.-O, ainsi que des procédés convergents de synthèse de ceux-ci. L'approche générale de préparation est représentée par la synthèse du motif mucine qu'on trouve habituellement sur des surfaces de cellules de tumeurs épithéliales. La présente invention concerne en outre des compositions et des méthodes de traitement du cancer au moyen des glycoconjugués à liaison .alpha.-O.
Chen Xiao Tao
Danishefsky Samuel J.
Glunz Peter
Hintermann Samuel
Kudryashov Valery
Robic
Sloan-Kettering Institute For Cancer Research
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