C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 5/08 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) C07K 5/02 (2006.01) C07K 5/083 (2006.01) C07K 5/087 (2006.01) C12Q 1/00 (2006.01) C12Q 1/37 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2411545
The prodrug of the invention is a modified form of a therapeutic agent and comprises a therapeutic agent, an oligopeptide of three amino acids, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by a trouase enzyme such as Thimet oligopeptidase. Also disclosed are methods of making and using the prodrug compounds.
La présente invention concerne un promédicament constituant une forme modifiée d'un agent thérapeutique et comprenant un agent thérapeutique, un oligopeptide de trois acides aminés, un groupe de stabilisation et, en option, un groupe de liaison. Ce promédicament est clivable par un enzyme trouase tel que Thimet oligopeptidase. L'invention concerne également des procédés de production et d'utilisation desdits composés pour promédicaments.
Bebbington Christopher R.
Dubois Vincent
Gangwar Sanjeev
Lobl Thomas J.
Nieder Matthew H.
Fetherstonhaugh & Co.
Medarex Inc.
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