Trisubstituted amines as phosphodiesterase 4 inhibitors

Details Trisubstituted amines as phosphodiesterase 4 inhibitors Trisubstituted amines as phosphodiesterase 4 inhibitors

C - Chemistry, Metallurgy

07

D

C07D 211/58 (2006.01) A61K 31/4427 (2006.01) A61K 31/4468 (2006.01) A61P 29/00 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 409/14 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2611562

PDE4 inhibition is achieved by novel compounds,' e.g., N-substituted diarylamine analogs. The compounds of the present invention are of Formulas I- III; (I), (II) and (III) wherein A, B, D, E, G, J, K, R1, R2, R3, R4, R11, R12, R13, R14, R21, R22, R23 and R24 are as defined herein.

L'invention concerne l'inhibition de la PDE4 par des composés nouveaux, par exemple des analogues de diarylamines N-substituées. Ces composés sont des formules I-III; dans lesquelles A, B, D, E, G, J, K, R1, R2, R3, R4, R11, R12, R13, R14, R21, R22, R23 et R24 sont tels que définis dans le descriptif.

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