Trivalent chromium compounds, compositions and methods of use

Details Trivalent chromium compounds, compositions and methods of use Trivalent chromium compounds, compositions and methods of use

A - Human Necessities

61

K

A61K 31/28 (2006.01) A61K 31/4406 (2006.01) A61K 33/24 (2006.01) A61K 36/185 (2006.01) A61K 36/22 (2006.01) A61K 36/38 (2006.01) A61K 36/49 (2006.01) A61K 36/54 (2006.01) A61K 36/82 (2006.01) A61P 7/00 (2006.01) C07C 55/22 (2006.01) C07C 57/48 (2006.01) C07C 65/03 (2006.01) C07C 229/76 (2006.01) C07F 11/00 (2006.01)

Patent

CA 2649103

The present invention provides chromium compounds which possess the ability to improve insulin sensitization, glucose tolerance, blood lipid metabolism, lean body mass, bioavailability, and safety as compared to chromium nicotinate, chromium picolinate and chromium histidine. These compounds are screened in terms of solubility, in vitro insulin sensitization, stability, and absorption as compared to chromium nicotinate, chromium picolinate and chromium histidine. The most promising chromium compounds are tested for their animal in vivo bioavailability, glucose metabolism, lipid metabolism and acute toxicity.

La présente invention concerne des composés à base de chrome ayant la capacité d'améliorer la sensibilisation à l'insuline, la tolérance au glucose, le métabolisme lipidique du sang, la masse du corps excluant la graisse, la biodisponibilité, et la sécurité par rapport au nicotinate de chrome, au picolinate de chrome et à l'histidine de chrome. Ces composés sont sélectionnés en termes de solubilité, sensibilisation à l'insuline in vitro, stabilité, et absorption par rapport au nicotinate de chrome, au picolinate de chrome et à l'histidine de chrome. Les composés à base de chrome les plus prometteurs sont testés pour leur disponibilité, leur métabolisme du glucose, le métabolisme lipidique et la toxicité aiguë sur des animaux in vivo.

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