Tuberculosis vaccines comprising antigens expressed during...

C - Chemistry – Metallurgy – 07 – K

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C07K 14/35 (2006.01) A61K 39/04 (2006.01) A61P 31/06 (2006.01)

Patent

CA 2612900

The invention is related to an immunogenic composition, vaccine or pharmaceutical composition for preventing, boosting or treating infection caused by a species of the tuberculosis complex (M tuberculosis, M. bovis, M. africanum, M. microti). The immunogenic composition, vaccine or pharmaceutical composition comprise a fusion polypeptide, which comprises one or more starvation antigens from M. tuberculosis, the units of the fusion polypeptide being M. tuberculosis antigens. Further, the invention is related to the use of a vaccine comprising a fusion polypeptide sequence or nucleic acid sequence of the invention given at the same time as BCG, either mixed with BCG or administered separately at different sites or routes for preparing said immunogenic composition, vaccine, or pharmaceutical composition.

L'invention concerne une composition immunogène, un vaccin ou une composition pharmaceutique destinés à la prévention, à la stimulation immunitaire ou au traitement d'une infection causée par une espèce du complexe tuberculosis (M. tuberculosis, M. bovis, M. africanum, M. microti). Cette composition immunogène, ce vaccin ou cette composition pharmaceutique comprennent un polypeptide hybride, y compris un ou plusieurs antigènes induits par une période de sous-alimentation de M. tuberculosis, les unités du polypeptide hybride étant des antigènes de M. tuberculosis. L'invention concerne également l'utilisation d'un vaccin comprenant une séquence polypeptidique hybride ou une séquence nucléotidique de l'invention, administré en même temps que le BCG, soit mélangé avec le BCG, soit administré séparément dans des sites différents ou par des voies différentes. L'invention concerne également des méthodes destinées à la préparation de cette composition immunogène, de ce vaccin ou de cette composition pharmaceutique.

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