Tumor antigen based on products of the tumor suppressor gene...

Details Tumor antigen based on products of the tumor suppressor gene... Tumor antigen based on products of the tumor suppressor gene...

C - Chemistry, Metallurgy

07

K

C07K 14/82 (2006.01) A61K 39/00 (2006.01) C07K 7/00 (2006.01) C12N 15/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2337743

Cancer antigens containing as the active ingredient a Wilms' tumor suppressor gene WT1 product or a peptide consisting of 7 to 30 consecutive amino acids in the amino acid sequence of the above gene containing an anchor amino acid binding to major histocompatibility complex (MHC) class I, and cancer vaccines containing the same.

Cette invention concerne des antigènes contre le cancer qui contiennent en qualité d'ingrédient actif un produit de gène suppresseur de tumeur de Wilms WT1 ou, encore, un peptide comprenant de 7 à 30 acides aminés consécutifs dans la séquence d'acides aminés du gène susmentionné, lesquels comprennent un acide aminé d'ancrage qui se lie au complexe d'histocompatibilité majeur (MHC) de classe I. Cette invention concerne également des vaccins contre le cancer qui contiennent ces antigènes.

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