Tumor necrosis factor muteins

Details Tumor necrosis factor muteins Tumor necrosis factor muteins

C - Chemistry, Metallurgy

12

N

C12N 15/28 (2006.01) A61K 38/19 (2006.01) A61K 39/39 (2006.01) C07H 21/02 (2006.01) C07K 14/525 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2119089

Tumor Necrosis Factor Muteins Abstract Human TNF muteins having higher binding affinity for human p75-TNF receptor than for human p55-TNF receptor include muteins having at least one deffect amino acid relative to wild-type human TNF at a position corresponding to position 33, 65, 67, 75, 87, 143, 145 or 147 of the wild-type amino acid sequence. Such muteins can be used to characterise human p75-receptor and, together with known muteins with selective binding affinity for human p55-TNF receptor, can aid in distinguishing between TNF functions mediated via binding to human p75-receptor and those mediated via binding to human p55-receptor. (Fig. 4 suggested to accompany abstract).

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