Tyrosine kinase inhibitors

Details Tyrosine kinase inhibitors Tyrosine kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61K 31/535 (2006.01) A61K 41/00 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2366644

The present invention relates to compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angiogenesis, cancer, tumor growth, atherosclerosis, age related macular degeneration, diabetic retinopathy, inflammatory diseases, and the like in mammals.

La présente invention concerne des composés qui inhibent, régulent et/ou modulent la transduction de signal de la tyrosine kinase. Cette invention concerne également des compositions renfermant ces composés, ainsi que des méthodes d'utilisation de ces compositions pour traiter les maladies et les troubles dépendant de la tyrosine kinase, par exemple l'angiogenèse, le cancer, la croissance tumorale, l'athérosclérose, la dégénérescence maculaire liée à l'âge, la rétinopathie diabétique, les maladies inflammatoires, et d'autres dysfonctionnements similaires chez les mammifères.

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