Ultrashort acting hypnotic barbiturates

Details Ultrashort acting hypnotic barbiturates Ultrashort acting hypnotic barbiturates

C - Chemistry, Metallurgy

07

D

C07D 239/62 (2006.01) A61K 31/515 (2006.01) A61P 25/20 (2006.01) C07D 239/66 (2006.01)

Patent

CA 2404898

The subject invention concerns novel compounds that are useful as ultrashort acting hypnotic barbiturates. Specifically exemplified are derivatives of barbituric and thiobarbituric acids. They are rapidly metabolized by blood and tissue enzymes to form polar metabolites with no hypnotic activity and which are rapidly eliminated.

L'invention concerne de nouveaux composés utiles en tant que barbituriques hypnotiques à action ultrabrève. D'une manière spécifique, l'invention concerne des dérivés d'acides barbiturique et thiobarbiturique, lesquels sont rapidement métabolisés par le sang et les enzymes tissulaires de manière à former des métabolites polaires qui ne présentent pas d'activité hypnotique et sont rapidement éliminés.

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