Urokinase-type plasminogen activator receptor

Details Urokinase-type plasminogen activator receptor Urokinase-type plasminogen activator receptor

C - Chemistry, Metallurgy

12

N

C12N 15/58 (2006.01) A61K 38/18 (2006.01) A61K 38/49 (2006.01) A61K 38/55 (2006.01) A61K 39/395 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 9/72 (2006.01) C12P 21/08 (2006.01) C12Q 1/68 (2006.01) G01N 33/573 (2006.01) G01N 33/574 (2006.01) G01N 33/86 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2051676

2051676 9012091 PCTABS00002 Pure human cellular receptor for urokinase plasminogen activator (u-PAR) and forms thereof, including a truncated water-soluble form produced by cleaving or removing a glycosyl-phosphatidylinositol anchor, are provided, as is cDNA for u-PAR. Cell surface plasminogen activation, believed to play an important role in tissue remodelling, particularly during cancer invasion, is inhibited by antibodies against u-PAR and by inactivated analogues of u-PA. In situ hybdridization showed presence of u-PAR mRNA in the invasion front of colon carcinomas, proving the diagnostic utility of the cDNA. Water-soluble u-PAR is useful for inhibition of u-PA catalyzed plasminogen activation in solution.

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