Use of 1,3,5-triazepin-2,6-diones to treat malaria

Details Use of 1,3,5-triazepin-2,6-diones to treat malaria Use of 1,3,5-triazepin-2,6-diones to treat malaria

A - Human Necessities

61

K

A61K 31/55 (2006.01) A61K 31/395 (2006.01) A61P 31/18 (2006.01) A61P 33/06 (2006.01)

Patent

CA 2635356

The present invention relates to various novel substituted dipeptide derived nitrogen-containing heterocyclic compounds, their pharmaceutically acceptable salt derivatives, and their methods of use. In one aspect the present invention relates to compositions and methods for the treatment and prevention of disease in a mammal comprising administering the compounds of the invention in a pharmaceutically acceptable form to a mammal. In particular, the invention relates to medicaments comprising various novel substituted dipeptide derived nitrogen- containing heterocyclic compounds and pharmaceutically acceptable salt derivatives and methods for administration to a mammal for the treatment and prevention of malarial diseases. The compounds of the invention may optionally be administered with at least one pharmaceutically acceptable excipient, another biologically active agent or a combination thereof.

La présente invention concerne divers nouveaux composés hétérocycliques contenant de l'azote dérivés de dipeptides substitués, leurs dérivés de sels de qualité pharmaceutique, et leurs méthodes d'utilisation. Un aspect de la présente invention concerne des compositions et des méthodes destinées au traitement et à la prévention de maladies chez un mammifère, ces méthodes consistant à administrer les composés de l'invention dans une forme de qualité pharmaceutique à un mammifère. Plus particulièrement, l'invention concerne des médicaments comprenant divers nouveaux composés hétérocycliques contenant de l'azote dérivés de dipeptides substitués, des dérivés de sels de qualité pharmaceutique et des méthodes d'administration destinés au traitement et à la prévention de maladies paludéennes. Les composés de l'invention peuvent éventuellement être administrés avec au moins un excipient de qualité pharmaceutique et/ou un autre principe actif.

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