A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/35 (2006.01) A61K 31/353 (2006.01) A61K 31/40 (2006.01) A61K 31/4025 (2006.01)
Patent
CA 2208859
The present invention provides novel uses of compounds of general formula (I) wherein R1, R4 and R5 are individually hydrogen, hydroxy, halogen, trifluoromethyl, lower alkyl, lower alkoxy or (tertiary amino)(lower alkoxy); and R2 and R3 are individually hydrogen or lower alkyl, or as a pharmaceutically acceptable salt thereof in combination with a pharmaceutically acceptable carrier for the manufacture of a pharmaceutical composition for the treatment or prophylaxis of hyperlipoproteinaemia, hypertriglyceridaemia, hyperlipidaemia or hypercholesterolaemia or arteriosclerosis or for anticoagulative treatment.
On décrit de nouvelles utilisations de composés de formule I dans laquelle R1, R4 et R5 représentent individuellement hydrogène, hydroxy, halogène, trifluorométhyle, alkyle inférieur, alcoxy inférieur ou (alcoxy inférieur)(amino tertiaire); et R2 et R3 représentent individuellement hydrogène ou alkyle inférieur. Ces composés, ou un de leurs sels pharmaceutiquement acceptables, combinés avec un vecteur pharmacologiquement acceptable, permettent d'obtenir une composition pharmaceutique servant au traitement ou à la prophylaxie de l'hyperlipoprotéinémie, de l'hypertriglycéridémie, de l'hyperlipidémie, de l'hypercholestérolémie, de l'artériosclérose, ou bien ils servent de traitement anticoagulant.
Bain Steven
Guldhammer Birgitte Hjort
Hart Charles E.
Korsgaard Niels
Shalmi Michael
Mccarthy Tetrault Llp
Novo Nordisk A/s
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