A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/445 (2006.01) A61K 31/00 (2006.01) A61K 31/135 (2006.01) A61K 31/137 (2006.01) A61K 31/44 (2006.01) A61K 31/4409 (2006.01) A61K 31/4515 (2006.01) A61K 31/454 (2006.01) A61K 31/4545 (2006.01) A61K 31/505 (2006.01) A61K 31/517 (2006.01) A61K 31/55 (2006.01) C07C 211/30 (2006.01) C07C 215/50 (2006.01) C07C 215/52 (2006.01) C07C 217/58 (2006.01) C07C 217/60 (2006.01) C07D 211/58 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 495/06 (2006.01)
Patent
CA 2148839
A method of treating benign prostatic hyperplasia in a subject which comprises administering to the subject a therapeuti- cally effective amount of a compound which binds to a human .alpha.1C adrenergic receptor with a binding affinity greater than ten-fold higher than the binding affinity with which the compound binds to a human .alpha.1A adrenergic receptor, a human .alpha.1B s adrenergic receptor and a human histamine H1 receptor, and, binds to a human .alpha.2 adrenergic receptor with a binding affin- ity which is greater than ten-fold lower than the binding affinity with which the compound binds to such .alpha.1C adrenergic re- ceptor, Compounds meeting these criteria are provided.
Branchek Theresa A.
Chiu George
Forray Carlos C.
Gluchowski Charles
Hartig Paul R.
Gowling Lafleur Henderson Llp
Lundbeck H.
Synaptic Pharmaceutical Corporation
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