Use of amide complex compounds

Details Use of amide complex compounds Use of amide complex compounds

A - Human Necessities

61

K

167/46

A61K 49/00 (2006.01)

Patent

CA 2023363

ABSTRACT OF THE DISCLOSURE --------------- Complex compounds of general Formula I Image (I) wherein n means the number 0, 1 or 2, R1 and R2 are independently hydrogen atoms, lower alkyl groups, phenyl groups, benzyl groups or, if n is the number 0, also jointly a trimethylene or a tetramethylene group, R3 is a saturated, unsaturated, straight-chain or branched-chain or cyclic aliphatic hydrocarbon residue of up to 16 carbon atoms or, if R4 is a hydrogen atom, a cycloalkyl group or an aryl or aralkyl group optionally substituted by one or several di-C1-C6- alkylamino groups or by one or several C1-C6-alkoxy groups, R4 is a hydrogen atom, a saturated, unsaturated, straight-chain or branched-chain or cyclic hydrocarbon residue of up to 16 carbon atoms, or R3 and R4 jointly mean a saturated or unsaturated 5- or 6-member ring which is optionally substituted by one or several C1-C6- alkyl, C1-C5-hydroxyalkyl residues, an optionally hydroxylated or Cl-C6- alkoxylated C2-C6-acyl residue, a hydroxy residue, a carbamoyl residue, a carbamoyl- substituted Cl-C6-alkyl residue, a carbamoyl residue substituted on the carbamoyl nitrogen by one or two Cl-C6- alkyl residue(s) -- which can also form a ring containing, if desired, an oxygen atom -- or a C1-C6-acylamino or C1-C6- alkylamino residue, this 5- or 6-membered ring optionally containing a further nitrogen, oxygen or sulfur atom, or a carbonyl group, X is a hydrogen atom and/or a metal ion equivalent of at least one element of atomic numbers 21-29, 42, 44 or 58-70, Y is a COOX- or Image group, with the proviso that at least two of the substitu- ents X stand for a metal ion equivalent, as well as their salts with organic and/or inorganic bases, are valuabe compounds for the organ-specific NMR diagnostics and in case of patients with renal insufficiency. .1.

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