Use of an aldosterone antagonist for treating restenosis

Details Use of an aldosterone antagonist for treating restenosis Use of an aldosterone antagonist for treating restenosis

A - Human Necessities

61

K

A61K 31/585 (2006.01) A61K 31/00 (2006.01) A61K 31/58 (2006.01) A61P 9/00 (2006.01) A61P 9/14 (2006.01) C12N 9/10 (2006.01)

Patent

CA 2390561

The present invention provides methods of treating, inhibiting or preventing pathogenic change resulting from vascular injury in a subject, particularly restenosis resulting substantially from angioplasty. The methods comprise administering a therapeutically-effective amount of an aldosterone antagonist, particularly eplerenone, in a mammalian subject susceptible to or suffering from said pathogenic change.

L'invention concerne des procédés pour le traitement, l'inhibition ou la prévention de modifications pathogènes résultant de lésions vasculaires chez un sujet, notamment de resténoses résultant essentiellement d'angioplasties. Les procédés selon l'invention comprennent l'administration d'une quantité efficace thérapeutiquement d'un antagoniste de l'aldostérone, notamment d'éplérénone, chez un sujet mammifère susceptible de souffrir ou souffrant d'une telle modification pathogène.

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