C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) A61K 31/00 (2006.01) A61K 31/137 (2006.01) A61K 31/145 (2006.01) A61K 45/00 (2006.01) A61K 49/00 (2006.01) A61P 9/00 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2421834
The present invention relates to the novel finding that inhibition of human CARP protein or of CARP DNA/mRNA may successfully cure heart disorders, especially heart failure in humans. The invention relates, therefore, to pharmaceutical compositions containing substances, preferably of lower molecular weight, which may influence the activity of cardiac CARP. The invention relates, furtheremore, to a method of treatment heart failure using CARP inhibitory compounds, to methods for screening these inhibitors and to the use of CARP as diagnostic tool.
L'invention concerne le fait que l'inhibition de la protéine CARP humaine ou de CARP ADN/ARNm, peut guérir efficacement des troubles cardiaques et en particulier des insuffisances cardiaques survenant chez des humains. L'invention concerne également des compositions pharmaceutiques contenant des substances, de préférence de poids moléculaire peu élevé pouvant influencer l'activité de CARP cardiaque. L'invention concerne aussi un procédé de traitement des insuffisances cardiaques grâce à l'utilisation de composants inhibiteurs de CARP, des procédés de dépistage de ces inhibiteurs et l'utilisation de CARP comme outil diagnostique.
Brandle Marian
Ehring Thomas
Eschenhagen Thomas
Hentsch Bernd
Kluxen Franz-Werner
Fetherstonhaugh & Co.
Merck Patent Gesellschaft Mit Beschraenkter Haftung
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