C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/04 (2006.01) A61K 31/34 (2006.01) A61K 31/381 (2006.01) A61K 31/40 (2006.01) C07D 207/30 (2006.01) C07D 307/34 (2006.01) C07D 409/04 (2006.01)
Patent
CA 2507545
The invention provides the use of a compound for the treatment of sickle cell disease. The compound has the structure: (see formula I) wherein R1 is CHO, or an aldehyde protecting group selected from the group consisting of: (see formula II) and (see formula III) n=0-4, and R2 is selected from the group consisting of hydroxymethyl, ethyl and methyl.
La présente invention a trait à des composés pour le traitement de la drépanocytose. En particulier, l'invention a trait à des agents anti-drépanocytaires hétérocycliques à 5 chaînons qui sont non toxiques et présente une grande efficacité, et leurs procédés d'utilisation. Les composés comprennent les analogues et les dérivés de 5-hydroxyméthyl-2-furfuraldéhyde, 5-éthyl-2-furfuraldéhyde, 5-méthyl-2-furfuraldéhyde, et 2-furfuraldéhyde, et de prodrogues du composé.
Abraham Donald J.
Burnett James C.
Danso-Danquah Richmond
Joshi Gajanan S.
Musayev Faik N.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Virginia Commonwealth University
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