Use of n2o gas for treating chronic pain

Details Use of n2o gas for treating chronic pain Use of n2o gas for treating chronic pain

A - Human Necessities

61

K

A61K 33/00 (2006.01) A61K 9/00 (2006.01) A61K 9/12 (2006.01) A61P 19/02 (2006.01) A61P 21/00 (2006.01) A61P 25/00 (2006.01) A61P 25/04 (2006.01) A61P 25/06 (2006.01) A61P 29/00 (2006.01) A61P 29/02 (2006.01)

Patent

CA 2755780

The invention relates to a gas mixture that contains nitrous oxide (N2O) for use as a breathable drug for the treatment of chronic pain in a mammal, in particular a pain from neuropathic, iatrogenic, dysfunctional or inflammatory origin, in particular in humans. The proportion of N2O ranges from 15 to 45 vol. %. The gas mixture is administered for a sufficient duration for obtaining a delayed pain hypersensitivity reduction that can be observed at least 6 hours after the end of the inhalation of the gas mixture by said mammal. The pain hypersensitivity is selected from allodynias and hyperalgesias.

L'invention concerne un mélange gazeux contenant du protoxyde d'azote (N2O) pour une utilisation en tant que médicament inhalable pour le traitement curatif d'une douleur chronique chez un mammifère, notamment une douleur chronique d'origine neuropathique, iatrogène, dysfonctionnelle ou inflammatoire, en particulier chez l'être humain. La proportion de N2O est comprise entre 15 et 45 % en volume. Le mélange gazeux est administré pendant une durée suffisante pour obtenir une réduction de l'hypersensibilité à la douleur retardée observable au moins 6 heures après la fin de l'inhalation du mélange gazeux par ledit mammifère. L'hypersensibilité à la douleur est choisie parmi les allodynies et les hyperalgésies.

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