C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/57 (2006.01) A61K 31/70 (2006.01) A61K 38/48 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C07K 16/40 (2006.01) C12N 9/48 (2006.01) C12N 9/64 (2006.01) C12Q 1/37 (2006.01) A61K 35/00 (2006.01)
Patent
CA 2202622
The present invention relates to flea serine protease and aminopeptidase proteins; to flea serine protease and aminopeptidase nucleic acid molecules, including those that encode such proteins; to antibodies raised against such proteins; and to compounds that inhibit flea serine protease and/or aminopeptidase activities. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitors. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies, and/or inhibitors as well as the use of such therapeutic compositions to protect a host animal from flea infestation.
La présente invention se rapporte aux protéines sérine protéase et aminopeptidase de la puce, ainsi qu'aux molécules d'acide nucléique de sérine protéase et d'aminopeptidase de la puce, y compris celles codant ces protéines; à des anticorps dirigés contre ces protéines, et à des composés inhibant les activités de la sérine protéase et/ou de l'aminopeptidase de la puce. La présente invention se rapporte également à des procédés permettant d'obtenir ces protéines, ces molécules d'acide nucléique, ces anticorps et ces inhibiteurs. La présente invention se rapporte encore à des compositions thérapeutiques comprenant ces protéines, ces molécules d'acide nucléique, ces anticorps et/ou ces inhibiteurs, ainsi qu'à l'utilisation de ces compositions thérapeutiques afin de protéger un animal hôte d'une infestation par les puces.
Arfsten Ann
Dale Beverly
Frank Glenn R.
Grieve Robert B.
Heath Andrew
Heska Corporation
Johnson Ernest Peter
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