A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/517 (2006.01) A61K 31/17 (2006.01) A61K 31/53 (2006.01) A61P 31/04 (2006.01)
Patent
CA 2516942
A novel screening assay for identifying therapeutic agents and their cellular targets is described. The assay is useful in developing new antibacterial, antifungal, antiparasitic and anti cancer therapeutics. New inhibitors of dihydrofolate reductase (DHFR) have been identified using the assay of the present invention. Methods of treating diseases that benefit from an inhibition of DHFR are also described.
L'invention concerne un nouvel essai de criblage permettant d'identifier des agents thérapeutiques et leurs cibles cellulaires. Ledit essai permet de mettre au point de nouveaux agents thérapeutiques antibactériens, antifongiques, antiparasitaires et anticancéreux. Ledit essai a également permis d'identifier de nouveaux inhibiteurs de la dihydrofolate réductase (DHFR). L'invention concerne également des procédés de traitement de maladies qui s'appuient sur une inhibition de la DHFR.
Brown Eric D.
Cechetto Jonathan D.
Hartlen Rebecca
Juran Michela
Li Xiaoming
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Mcmaster University
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