Use of reboxetine for the treatment of pain

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/5375 (2006.01) A61P 25/02 (2006.01)

Patent

CA 2567365

Use of (S,S)- or racemic reboxetine or a pharmaceutically acceptable salt thereof in the manufacture of a medicament for the treatment of a pain condition selected from neuropathic pain, nociceptive pain, cancer pain, back pain, inflammatory pain, musculo-skeletal disorders, visceral pain, pain from strains/sprains, post-operative pain, posttraumatic pain, burns, renal colic, acute pain, central nervous system trauma, head pain, and orofacial pain, is disclosed. Use of (S,S)-reboxetine or a pharmaceutically acceptable salt thereof in the manufacture of a medicament for the treatment of pain in a patient refractory to an alpha-2-delta ligand, and use of (S,S)- or racemic reboxetine or a pharmaceutically acceptable salt thereof in the manufacture of a medicament for use as a mental performance or mood enhancer, are also disclosed.

L'invention porte sur l'utilisation de réboxétine-(S,S) ou de réboxétine racémique, ou d'un sel pharmaceutiquement acceptable de celles-ci pour la préparation d'un médicament destiné au traitement d'une douleur choisie parmi: les douleurs neuropathiques, les douleurs nociceptives, les douleurs cancéreuses, les dorsalgies, les douleurs inflammatoires, les troubles musculo-squelettiques, les douleurs viscérales, les douleurs accompagnant les foulures/entorses, les douleurs post-opératoires, les brûlures, les coliques néphrétiques, les douleurs aiguës, les traumatismes du système nerveux central, les céphalées, et les douleurs oro-faciales. L'invention concerne également l'utilisation de (S,S)-réboxétine ou d'un sel pharmaceutiquement acceptable de celle-ci pour la préparation d'un médicament destiné au traitement de la douleur chez un patient réfractaire aux ligands alpha 2-delta, et l'utilisation de réboxétine-(S,S) ou racémique, ou d'un sel pharmaceutiquement acceptabe de celles-ci, pour la préparation d'un médicament agissant comme stimulateur des performances intellectuelles ou régulateur de l'humeur.

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