A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4545 (2006.01) A61P 25/06 (2006.01)
Patent
CA 2594096
The invention relates to a method for treating or preventing headaches, migraine, or cluster headache. Said method comprises jointly administering a therapeutically effective amount of a selected CGRP antagonist (A), a physiologically acceptable salt thereof or a hydrate of said salt, and a therapeutically effective amount of a second or third active antimigraine medical substance (B), particularly sumatriptan, zolmitriptan, or dihydroergotamine or a physiologically acceptable salt thereof. Also disclosed are the corresponding pharmaceutical compositions and the production thereof.
L'invention concerne un procédé pour traiter ou prévenir des céphalées, migraines, ou céphalées vasculaires de Horton. Ce procédé consiste à administrer une dose thérapeutiquement efficace d'un antagoniste (A) sélectionné du peptide lié au gène de la calcitonine (CGRP), d'un sel physiologiquement acceptable de cet antagoniste, ou d'un hydrate de ce sel, en association avec une dose thérapeutiquement efficace d'une deuxième ou d'une troisième substance médicinale active contre la migraine (B), telles que les substances Sumatriptan, Zolmitriptan ou Dihydroergotamine, ou d'un sel physiologiquement acceptable correspondant. Cette invention concerne en outre les compositions pharmaceutiques correspondantes, et leur production.
Arndt Kirsten
Brickl Rolf-Stefan
Doods Henri
Lustenberger Philipp
Mueller Stephan Georg
Boehringer Ingelheim International Gmbh
Fetherstonhaugh & Co.
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