G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/566 (2006.01) C12Q 1/02 (2006.01) G01N 33/543 (2006.01)
Patent
CA 2452337
Assays for identifying compounds that modulate, preferably inhibit bitter taste associated with the activation of hT2R4, hT2R44 and/or hT2R61 are provided. The compounds identified according to these assays should modulate, e.g., inhibit bitter taste associated with bitter tasting compounds including quinine, 6-nitrosaccharin, saccharin and/or denatonium. These compounds are useful additives for foods, beverages or medicinal preparationshaving a bitter taste.
L'invention concerne des épreuves biologiques permettant d'identifier des composés qui modulent, de préférence inhibent un goût acide associé à l'activation de hT2R4, de hT2R44 et/ou de hT2R61. Les composés identifiés en fonction de ces épreuves biologiques doivent moduler, par exemple, inhiber un goût acide associé à des composés au goût acide comprenant la quinine, la 6-nitrosaccharine, la saccharine et/ou le denatonium. Ces composés constituent des additifs utiles pour des préparations alimentaires, médicinales, ou des préparations de boisson, présentant un goût acide.
Adler Jon Elliot
Brust Paul
Connor Judy
Keung Walter
O'connell Shawn
Gowling Lafleur Henderson Llp
Senomyx Inc.
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