Use of tff2, or agents inducing tff2, in the therapy of...

A - Human Necessities – 61 – K

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A61K 38/20 (2006.01) A61K 38/17 (2006.01) A61K 38/22 (2006.01) A61P 11/06 (2006.01) A61P 37/08 (2006.01) G01N 33/00 (2006.01)

Patent

CA 2512709

A composition and method for alleviation of an allergic response by regulation of trefoil factor-2 (TFF2) expression. TFF2 is also disclosed as a marker for assessment of an allergic patient's status, for example, monitoring inflammation and/or tissue repair in a lung of an asthmatic patient. Regulation of TFF2 is involved in the pathogenesis of allergic lung inflammation and other allergen-induced conditions, for example, up-regulation of TFF2 may exert a protective effect by reducing acid secretion and/or increasing epithelial cell proliferation to promote healing.

La présente invention concerne une composition et un procédé destiné à améliorer une réponse allergique par régulation de l'expression du facteur TFF2 (Trefoil factor 2). Selon l'invention, le TFF2 est également un marqueur permettant de vérifier l'état d'un patient allergique, par exemple pour surveiller l'inflammation et/ou la réparation des tissus dans un poumon d'un patient asthmatique. La régulation du TFF2 est impliquée dans la pathogenèse des inflammations pulmonaires allergiques et d'autres états induits par des allergènes, par exemple, une remontée provoquée des taux de TFF2 peut provoquer un effet de protection par réduction des sécrétions acides et/ou accroissement de la prolifération des cellules épithéliales de façon à favoriser la guérison.

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