V.alpha.12.1 t-cell receptor-specific reagents for...

Details V.alpha.12.1 t-cell receptor-specific reagents for... V.alpha.12.1 t-cell receptor-specific reagents for...

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) C07K 14/725 (2006.01) C07K 16/02 (2006.01) G01N 33/50 (2006.01) G01N 33/564 (2006.01) G01N 33/569 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2116339

2116339 9304700 PCTABS00020 Provided are monoclonal antibodies, fragments, and derivatives thereof reactive with an epitope of the T cell receptor alpha chain variable region, V.alpha.12.1, on human T lymphocytes. The monoclonal antibodies are reactive with approximately 2 % of CD4+ T lymphocytes and with approximately 5 % of CD8+ T lymphocytes in peripheral blood cells in normal individuals and define a subset of individuals afflicted with an autoimmune disease, especially rheumatoid arthritis, that exhibit increased expression of the V.alpha.12.1 gene on CD8+ peripheral blood T lymphocytes when compared to normal individuals. Also provided are methods for diagnosing, treating, and monitoring the progression of rheumatoid arthritis in a subject using V.alpha.12.1-specific reagents, especially the monoclonal antibodies, fragments, and derivatives of the invention, that bind to a cellular component of T cells and detect V.alpha.12.1 gene usage. Higher levels of assurance in the diagnosis of RA can be made by establishing that the expansion of V.alpha.12.1 gene usage is clonal or oligoclonal and that the V.alpha.12.1 expansion correlates with the occurrence ofthe MHC allele, HLA-DQw2.

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