Vaccinal fluid water-in-oil emulsions containing a...

A - Human Necessities – 61 – K

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A61K 47/14 (2006.01) A61K 9/00 (2006.01) A61K 9/107 (2006.01) A61K 39/00 (2006.01) A61K 39/39 (2006.01) A61K 47/24 (2006.01)

Patent

CA 2135192

Metabolizable oil-based water-in-oil vaccinal emulsions which are stable and fluid at 4°C containing: from to 50 v/v % of an antigen-containing aqueous phase, preferably from 12 to 25 v/v %, from 50 to 94 v/v % of an oil phase containing in total or in part a metabolizable oil (vegetable oil, or fatty acid, polyol or alcohol esters), from 0.2 to 20 p/v % of surfactants, preferably from 3 to 8 p/v %, the latter being in total or in part, or in a mixture either polyglycerol esters, said polyglycerol esters being preferably polyglycerol (poly)ricinoleates, or polyoxyethylene ricin oils or else hydrogenated polyoxyethylene ricin oils.

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