A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/385 (2006.01) A61K 39/00 (2006.01) A61K 39/39 (2006.01) C07K 14/485 (2006.01)
Patent
CA 2137639
The invention provides novel uses of EGF and vaccine compositions comprising EGF. In particularly autologous EGF, or a fragment or a derivative thereof is used as an active immunisation against the proliferation of EGF-dependent tumours, or other EGF-dependent diseases. Autologous EGF is preferably coupled to a carrier protein, such as Tetanus Toxoid or Cholera toxin B chain. The vaccine compositions according to the invention will usually comprise an adjuvant such aluminium hydroxide.
L'invention fournit des utilisations nouvelles du facteur de croissance épidermique (EGF) et des compositions de vaccins à base d'EGF. En particulier, un EGF autologue ou un fragment ou dérivé correspondant est utilisé comme immunisation active contre la prolifération des tumeurs ou d'autres maladies dépendantes de l'EGF. L'EGF autologue est couplé de préférence à une protéine-support comme l'anatoxine tétanique ou la chaîne B de la toxine cholérique. Les compositions de vaccins dévoilées comprendront habituellement un adjuvant comme l'hydroxyde d'aluminium.
Davila Agustin B. L.
Delgado Irene B.
Gandolf Gilda N.
Marinello Gisela G.
Peztana Eduardo S.
Centro de Inmunologia Molecular
Macrae & Co.
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