Vaccine comprising an immunogenic protein and, as an...

Details Vaccine comprising an immunogenic protein and, as an... Vaccine comprising an immunogenic protein and, as an...

C - Chemistry, Metallurgy

07

K

167/130

C07K 14/105 (2006.01) A61K 39/12 (2006.01) A61K 39/00 (2006.01)

Patent

CA 1292690

A B S T R A C T The invention relates to a new vaccine comprising a native protein capable of inducing the production of protective antibodies in a host, together with an adjuvant amount of certain proteins or peptides which, as such, are not capable of inducing substantial protective antibody titres but considerably enhance the immunizing activity of said native protein. The amino acid sequences of the adjuvant proteins and peptides show homology with the native proteins. Combination of inactivated picornavirus, such as poliovirus, with adjuvant amounts of de- natured picornavirus, such as poliovirus, capsid proteins, in a vaccine, is highly advantageous. ******

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