Vaccine for pseudomonas aeruginosa

Details Vaccine for pseudomonas aeruginosa Vaccine for pseudomonas aeruginosa

C - Chemistry, Metallurgy

07

K

C07K 14/21 (2006.01) A61K 39/104 (2006.01) A61K 39/385 (2006.01)

Patent

CA 2328495

A C-terminal pilin peptide vaccine for immunizing or treating a patient for infection by a Pseudomonas aeruginosa (PA) infection is disclosed. The peptide comprises the peptide identified as SEQ ID NOS: 3-6; and a carrier protein conjugated to the peptide. Also disclosed is a pilin peptide C-terminal PA pilin peptide having the amino acid sequence identified as SEQ ID NO: 3, and analogs thereof having one of residues T, K, or A at position 130, D, T, or N at position 132, Q, A, or V at position 133, E, P, N, or A at position 135, Q, M, or K at position 136, and I, T, L, or R at position 138, excluding SEQ ID NOS: 1, 2, 9, 10, and 11, and the ability to cross-react with antibodies against the corresponding C-terminal peptides from PA stains PAK and PAO.

Vaccin de peptide de piline d'extrémité C servant à immuniser ou à traiter un patient contre une infection provoquée par Pseudomonas aeruginosa (PA). Ce peptide consiste en celui qui est identifié en tant que SEQ ID NOS: 3-6 et en une protéine de support conjuguée à ce peptide. L'invention concerne également un peptide de piline d'extrémité C de PA possédant la séquence aminoacide identifiée en tant que SEQ ID NO: 3 et ses analogues possédant un des résidus T, K ou A en position 130, D, T ou N en position 132, Q, A ou V en position 133, E, P, N ou A en position 135, Q, M ou K en position 136 et I, T, L ou R en position 138, à l'exclusion de SEQ ID NOS: 1, 2, 9, 10 et 11, et présentant la capacité d'opérer une réaction croisée avec des anticorps contre les peptides d'extrémité C correspondants provenant de souches de PA PAK et PAO.

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