Vaccine preparations containing saponins

Details Vaccine preparations containing saponins Vaccine preparations containing saponins

A - Human Necessities

61

K

A61K 39/39 (2006.01)

Patent

CA 2344336

Adjuvants containing as the active ingredient saponins having a presenegenin skeleton as the mother nucleus and being substituted at the 28-position by an optionally substituted sugar residue; and vaccine preparations containing these adjuvants. For example, a sufficient immune stimulation activity can be exhibited even by transnasal vaccination by using a saponin having structure (I).

L'invention a pour objet des adjuvants contenant à titre de principe actif des saponines ayant pour noyau-mère un squelette de preségenine et étant substitué à la position 28 par un reste de sucre éventuellement substitué. L'invention concerne également des préparations vaccinales contenant de tels adjuvants. Par exemple, une activité suffisamment immunostimulante peut être réalisée même par une vaccination transnasale mettant en oeuvre une saponine ayant la structure (I).

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