Vaccines and methods for treatment or prevention of...

A - Human Necessities – 61 – K

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A61K 39/112 (2006.01) A61K 39/39 (2006.01) A61P 31/04 (2006.01) A61P 37/04 (2006.01) C12N 1/20 (2006.01)

Patent

CA 2662174

Vaccine compositions comprising isolated Salmonella spp. cell culture supernatant for the prevention and treatment of Salmonella spp. infection are provided. The culture supernatant is produced under Salmonella pathogenicity island 2 (SPI-2) inducing conditions by incubating Salmonella spp. cells in a low phosphate and low magnesium medium (LPM). Methods for reducing colonization and shedding of Salmonella spp. in a subject by administration of the vaccine compositions are also provided.

La présente invention concerne des procédés pour le traitement ou la prévention d'infection par des bactéries Gram négatif, telles que des espèces Salmonella, chez un sujet vertébré. Les procédés comprennent l'administration d'un antagoniste de systèmes de sécrétion de type III au sujet vertébré en une quantité efficace pour réduire ou éliminer l'infection bactérienne par une espèce Salmonella. L'invention concerne en outre des procédés pour le traitement ou la prévention d'infection par des espèces Salmonella chez des espèces aviaires ou mammifères.

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