A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/19 (2006.01) A61K 31/00 (2006.01) A61K 31/20 (2006.01) A61K 31/203 (2006.01) A61K 31/28 (2006.01) A61K 31/282 (2006.01) A61K 31/59 (2006.01) A61K 31/593 (2006.01) A61K 41/00 (2006.01) A61K 45/06 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2460713
The present invention relates to the use of the drug valproic acid and derivatives thereof as inhibitors of enzymes having histone deacetylase for the sensitizing treatment of human cancers in combination with established therapeutic principles. The invention also relates to the use of those compounds for the treatment of tumor metastasis and minimal residual disease. Another aspect of the invention is a method for the identification of substance being useful for combinatorial cancer therapy and a diagnostic method to identify tumors comprising the step of testing in vitro whether a tumor is responsive to treatment with combinations of VPA or derivatives thereof and established tumor therapeutics.The invention includes the manufacture of a clinically used substance for the treatment of human cancers.
L'invention se rapporte à l'utilisation de l'acide valproïque et de ses dérivés, tels que des inhibiteurs d'enzymes ayant une activité d'histone déacétylase pour le traitement sensibilisateur des cancers humains en combinaison avec les principes thérapeutiques établis. L'invention se rapporte également à l'utilisation de ces composés dans le traitement de la métastase d'une tumeur et d'une maladie résiduelle minimale. L'invention se rapporte en outre à la préparation d'une substance utilisée cliniquement dans le traitement de cancers humains.
Goettlicher Martin
Groner Bernd
Heinzel Thorsten
Hentsch Bernd
Herrlich Peter A.
G2m Cancer Drugs Ag
Goudreau Gage Dubuc
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