Vanilloid receptor ligands and their use in treatments

Details Vanilloid receptor ligands and their use in treatments Vanilloid receptor ligands and their use in treatments

C - Chemistry, Metallurgy

07

D

C07D 405/12 (2006.01) A61K 31/506 (2006.01) A61P 29/00 (2006.01) C07D 239/48 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 405/14 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2579143

Substituted pyridines and pyrimidines and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

L'invention concerne des pyridines et pyrimidines substituées et des compositions les contenant utilisées dans le traitement de douleurs aiguës, inflammatoires et neuropathiques, de maux de dents, de maux de tête, de migraine, de céphalée de Horton, de syndromes vasculaires mixtes et non vasculaires, de céphalée de tension, d'inflammation traditionnelle, d'arthrite, de rhumatismes, d'ostéoarthrite, de maladies intestinales inflammatoires, de troubles oculaires inflammatoires, de troubles de la vessie inflammatoires ou instables, du psoriasis, des symptômes cutanés à composante inflammatoire, de troubles inflammatoires chroniques, de douleurs inflammatoires et d'hyperalgésie et d'allodynie liées, de douleurs neuropathiques diabétiques, de causalgie, de douleurs persistantes, de syndromes de désafférentation, d'asthme, de dysfonctionnement ou de dégâts tissulaires épithéliaux, d'herpès, de perturbations de la motilité viscérale au niveau de régions respiratoires, génito-urinaires, gastro-intestinales ou vasculaires, de blessures, de brûlures, de réactions cutanées allergiques, du prurit, du vitiligo, de troubles gastro-intestinaux traditionnels, d'ulcère gastrique, d'ulcères duodénaux, de diarrhée, de lésions gastriques induites par des agents nécrosants, de croissance capillaire, de rhinite vasomotrice ou allergique, de troubles des bronches ou de la vessie.

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