Variants derived from actriib and uses therefor

Details Variants derived from actriib and uses therefor Variants derived from actriib and uses therefor

C - Chemistry, Metallurgy

07

K

C07K 14/71 (2006.01) A61K 38/17 (2006.01) A61K 38/18 (2006.01) C07K 14/705 (2006.01) C07K 19/00 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2677160

In certain aspects, the present invention provides compositions and methods for modulating (promoting or inhibiting) growth of a tissue, such as bone, cartilage, muscle, fat, and/or neuronal tissue. The present invention also provides methods of screening compounds that modulate activity of an ActRIIB protein and/or an ActRIIB ligand. The compositions and methods provided herein are useful in treating diseases associated with abnormal activity of an ActRIIB protein and/or an ActRIIB ligand.

L'invention concerne des compositions et des procédés pour moduler (favoriser ou inhiber) la croissance d'un tissu, tel qu'un tissu osseux, un tissu cartilagineux, un tissu musculaire, un tissu adipeux, et/ou un tissu neuronal. La présente invention concerne également des procédés de criblage de composés modulant l'activité d'une protéine de ActRIIB et/ou d'un ligand de ActRIIB. Les compositions et les procédés fournis ci-dessus sont utiles pour traiter des maladies associées à une activité anormale d'une protéine de ActRIIB et/ou d'un ligand de ActRIIB.

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