C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/575 (2006.01) A61K 38/22 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2405689
The present invention encompasses novel analogs of vasoactive intestinal peptide (VIP), containing substitutions at appropriately selected amino acids. The invention particularly relates to the design and synthesis of novel biologically active VIP analogs containing .alpha., .alpha.-dialkylated amino acids in a site-specific manner. Specifically, the invention relates to the synthesis of VIP peptide derivatives, which bind selectively to VIP receptors on target cells. The invention encompasses methods for the generation of these peptides, compositions containing the peptides and the pharmacological applications of these peptides especially in the treatment and prevention of cancer.
L'invention concerne de nouveaux analogues peptidiques vasoactifs intestinaux (VIP) contenant des substitutions au niveau des acides aminés convenablement sélectionnés. L'invention concerne plus particulièrement la conception et la synthèse de nouveaux analogues VIP biologiquement actifs contenant des acides aminés .alpha., .alpha.-dialkylés de manière spécifique au site. L'invention concerne plus concrètement la synthèse de dérivés peptidiques VIP qui se lient de manière sélective aux récepteurs VIP sur les cellules cibles. L'invention concerne en outre des procédés permettant l'obtention de ces peptides et de compositions contenant les peptides ainsi que leurs applications pharmacologiques surtout dans le traitement et la prévention du cancer.
Burman Anand C.
Gupta Neena
Mathur Archna
Mukherjee Rama
Prasad Sudhanand
Dabur Research Foundation
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