Vinylphenol derivatives, their preparation and their use

Details Vinylphenol derivatives, their preparation and their use Vinylphenol derivatives, their preparation and their use

C - Chemistry, Metallurgy

07

C

167/245, 167/246

C07C 39/23 (2006.01) C07C 43/215 (2006.01) C07C 59/72 (2006.01) C07D 317/50 (2006.01)

Patent

CA 1338939

Disclosed are new vinylphenol derivatives of the formula I Image where A is a methylene or ethylene radical which is unsubstituted or substituted by C1-C4-alkyl, R1 and R are each hydrogen or methyl, R3 is hydrogen, C1-C4-alkyl, C1-C4- alkoxy or halogen, R4 is hydrogen, C1-C4-alkyl, cyclopropyl or cyclobutyl, R5 and R7 are each hydrogen or -OR8, where R8 is hydrogen, C1-C4-alkyl or C1-C4-alkanoyl, and R6 is hydrogen or is C1-C4-alkyl which is unsubstituted or substi- tuted by carboxyl, C1-C4-alkoxycarbonyl, hydroxyl, C1-C4- alkoxy and/or amino or mono- or di-C1-C4-alkylamino, or is C1-C20-alkanoyl or is benzoyl which is unsubstituted or substituted as described for the C1-C4-alkyl group, or is aralkyl which is unsubstituted or similarly substituted in the aryl moiety, and R6 and R8 together may furthermore form a radical C=O, C=S, -CH2CH2- or CR9R10 , where R9 and R10 are each hydrogen, C1-C4-alkyl or phenyl, and their physiologically tolerated salts. These derivatives are for the treatment of various disorders of the skin, the mucous membranes and the internal organs, and of rheumatic disorder.

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