(vinylphenyl)phenylmethane and method for producing...

Details (vinylphenyl)phenylmethane and method for producing... (vinylphenyl)phenylmethane and method for producing...

C - Chemistry, Metallurgy

07

C

260/515.3, 260/6

C07C 15/50 (2006.01) C07C 45/50 (2006.01) C07C 47/23 (2006.01) C07C 51/14 (2006.01) C07C 51/16 (2006.01) C07C 51/215 (2006.01) C07C 51/235 (2006.01) C07C 51/255 (2006.01) C07C 59/84 (2006.01)

Patent

CA 1302431

ABSTRACT OF THE DISCLOSURE The invention relates to a new compound of (3-Vinylphenyl)phenylmethane and a method for producing .alpha.-(3-benzoylphenyl)propionic acid of ketoprofen without difficulty at low cost and in a high yield. The method comprises the steps of: reacting (3-vinylphenyl)phenyl- methane with carbon monoxide and hydrogen, water or lower alcohol in the presence of a transition metal carbonylation catalyst to form .alpha.-(3-benzylphenyl)proplonic acid deriva- tive, and when the thus obtained compound is an aldehyde, oxidizing methylene group and formyl group of the compound simultaneously or sequentially, or when the obtained compound is an acid or its ester, oxidizing the methylene group of the compound, and if need be, it is followed by hydrolysis.

561701

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