Virally-safe factor viii with a low content of higher multimers

Details Virally-safe factor viii with a low content of higher multimers Virally-safe factor viii with a low content of higher multimers

C - Chemistry, Metallurgy

07

K

C07K 14/755 (2006.01) A61K 38/37 (2006.01) C07K 1/34 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2543095

La present invention pertains to a composition of plasma-derived virally-safe factor VIII, obtained after nanometric filtration, said composition comprising von Willebrand factor (vWF) at a rate of 15% or less of decamers and higher multimers. Such compositions have a reduction factor of the virus titre higher than 4 log and are thus suitable for treatment of hemophilia.

La présente invention se rapporte à une composition de Facteur VIII d~origine plasmatique sécurisé viralement, obtenue après filtration nanométrique, comprenant du Facteur von Willebrand (FvW) à un taux inférieur ou égal à 15 % des décamères et multimères supérieurs. De telles compositions présentent un facteur de réduction du titre des virus supérieur à 4 log et sont donc adaptées pour le traitement de l~hémophilie.

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