C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
167/115
C07K 14/52 (2006.01) A61K 35/22 (2006.01) A61K 38/00 (2006.01)
Patent
CA 1142431
ABSTRACT OF THE DISCLOSURE: A colony-stimulating factor having definite physical and chemical properties and a function of stimulat- ing activity on human bone marrow cells to proliferate and differentiate, thereby forming granulocyte colonies, is obtained from human urine by concentrating the urine with respect to proteins contained therein by adsorption chromatography with silica gel, salting out with ammonium sulfate and other means, then removing impurities by adsorption on cation exchanger, and further purifying by ion exchanging chromatography on anion exchanger, gel filtrating chromatography with highly crosslinked gels, affinity chromatography with sugar affinitive adsorbents and electrophoresis. This substance is stable in the presence of a stabilizer such as albumin or urinary proteins, against heat-treatment of virus- inactivation and can be used as a leukopenia curative which is precluded from fear of virus-infection.
327566
Funakoshi Satoshi
Kuboyama Morio
Nishida Masayuki
Ogasa Katsuhiro
Yamada Muneo
Fetherstonhaugh & Co.
Ltd. Morinaga Milk Industry Co.
Yoshitomi Pharmaceutical Industries Ltd.
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