Virus-like particles comprising a fusion protein of the coat...

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 19/00 (2006.01) A61K 39/00 (2006.01) A61P 37/00 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2580208

The present invention is in the fields of medicine, immunology, virology and molecular biology. The present invention provides a composition comprising a modified virus-like (VLP) particle derived from RNA bacteriophage AP205. The invention also provides a process for producing the aforementioned VLP. The modified VLP disclosed in the present invention is useful in the production of compositions for inducing immune responses for the prevention or treatment of diseases, disorders including infectious diseases, allergies, cancers and drug addiction. Moreover, the modified VLP disclosed in the present invention is, in particular, useful to efficiently induce self-specific immune responses, in particular antibody responses.

La présente invention concerne les domaines de la médecine, de l'immunologie, de la virologie et de la biologie moléculaire. La présente invention concerne une composition comprenant une particule ressemblant à un virus (VLP) modifiée dérivée de l'ARN du bactériophage AP205. L'invention concerne également un procédé servant à produire la VLP susmentionnée. La VLP modifiée exposée dans la présente invention est utile dans la production de compositions servant à induire des réponses immunitaires pour la prévention ou le traitement de maladies et de troubles dont des maladies infectieuses, des allergies, des cancers et la pharmacodépendance. De plus, la VLP modifiée exposée dans la présente invention est utile, en particulier, pour induire de façon efficace des réponses auto-immunitaires spécifiques, en particulier des réponses d'anticorps.

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