Volatilizable solid phase supports for compound synthesis

Details Volatilizable solid phase supports for compound synthesis Volatilizable solid phase supports for compound synthesis

C - Chemistry, Metallurgy

07

K

C07K 1/04 (2006.01) C07D 521/00 (2006.01) C07H 3/06 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01)

Patent

CA 2362193

A solid phase synthetic method is disclosed in which the usual solid phase synthetic steps are carried out and the spent solid phase support is reacted to form a volatilizable compound upon cleavage of the reaction product from the solid phase support. The cleaved product is then separated from the volatile compound by volatilization of that compound. Exemplary solid supports that form a volatilizable compound are also disclosed.

Cette invention concerne un procédé de synthèse en phase solide selon lequel on effectue les opérations courantes de synthèse en phase solide, puis où l'on fait réagir le support utilisé pendant la phase solide pour former un composé volatilisable au moment de la scission du produit de réaction à partir du produit en phase solide. Le produit scindé est ensuite séparé du composé volatile par volatilisation dudit composé. L'invention concerne également des supports solides types qui peuvent être formés à partir d'un composé volatilisable.

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