C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/435 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2262753
A novel class of peptides selectively block class E voltage-gated calcium channels. The class is exemplified by HG peptides such as HG-1, which is isolated from the venom-producing cells of the tarantula Hysterocrates gigas. Also disclosed are methods of producing blocking class E channels using the peptides. HG peptides have utility, for example, in inhibiting oxytocin release and for use as anticonvulsants.
L'invention porte sur une nouvelle classe de peptides bloquant sélectivement les canaux calciques activés par une tension E. Cette classe est illustrée par les peptides HG tels que le peptide HG-1 qui peut être isolé des cellules productrices de venin de la tarentule Histerocrates gigas. L'invention porte également sur des procédés de blocage de canaux de classe E à l'aide desdits peptides. Les peptides HG peuvent par exemple servir à inhiber la libération des oxytocines, et d'anticonvulsifs.
Bowersox Stephen Scott
Cong Ruth L.
Dean Robin
Hopkins William F.
Miljanich George P.
Elan Pharmaceuticals Inc.
Gowling Lafleur Henderson Llp
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