Vr1 vanilloid receptor antagonists with a iononic substructure

Details Vr1 vanilloid receptor antagonists with a iononic substructure Vr1 vanilloid receptor antagonists with a iononic substructure

C - Chemistry, Metallurgy

07

D

C07D 217/02 (2006.01) C07C 233/11 (2006.01) C07C 233/15 (2006.01) C07C 233/28 (2006.01) C07D 213/75 (2006.01) C07D 217/22 (2006.01)

Patent

CA 2657304

The invention provides compounds of formula (I), wherein Y, R, n and X are as defined in the description, a process for their preparation and pharmaceutical compositions containing them. The compounds of formula (I) inhibit the Transient Receptor Potential Vanilloid 1 (TRPV1 ), which plays a pivotal role in the development of post-inflammatory analgesia, therefore they can be used as analgesic and anti-inflammatory drugs.

La présente invention se rapporte à des composés représentés par la formule (I), dans laquelle Y, R, n et X sont tels que définis dans la description, à un procédé permettant de les préparer et à des compositions pharmaceutiques les contenant. Les composés représentés par la formule (I) inhibent le récepteur vanilloïde TRPV1 (Transient Receptor Potential Vanilloid 1), qui joue un rôle central dans le développement de l'analgésie post-inflammatoire, et peuvent donc servir de médicaments analgésiques et anti-inflammatoires.

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