C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 15/00 (2006.01) A61K 31/40 (2006.01) A61K 31/555 (2006.01) A61K 41/00 (2006.01) A61K 49/00 (2006.01) A61P 35/00 (2006.01) A61P 35/04 (2006.01) C07F 1/08 (2006.01) C07F 3/06 (2006.01) C07F 13/00 (2006.01)
Patent
CA 2506296
The invention provides anionic water-soluble tetracyclic and pentacyclic bacteriochlorophyll derivatives (Bchls) containing at least one, preferably two or three, negatively charged groups and/or acidic groups that are converted to negatively charged groups at the physiological pH, preferably Bchls having a group COO-, COS-, SO3-, PO32-, COOH, COSH, SO3H, and/or PO3H2 bound through an ester or amide bond to one or more of the positions 173, 133, and 32 of the tetracyclic or pentacyclic Bchl molecule, for photodynamic therapy and diagnosis.
L'invention concerne des dérivés bactériochlorophylles (Bchl) pentacycliques et tétracycliques solubles dans l'eau et anioniques contenant au moins, de préférence, deux ou trois groupes chargés négativement et/ou groupes acides convertis en groupes chargés négativement au pH physiologique. De préférence, les Bchl comportent un groupe COO?-¿, COS?-¿, SO¿3??-¿, PO¿3??2-¿, COOH, COSH, SO¿3?H, et/ou PO¿3?H¿2? liés par une liaison ester ou amide à une ou à plusieurs des positions 17?3¿, 13?3¿, et 3?2¿ de la molécule Bchl pentacyclique ou tétracyclique, pour un diagnostic et une thérapie photodynamique.
Brandis Alexander
Mazor Ohad
Salomon Yoram
Scheer Hugo
Scherz Avigdor
Borden Ladner Gervais Llp
Brandis Alexander
Ltd. Yeda Research And Development Co.
Mazor Ohad
Salomon Yoram
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