Water-soluble benzoazepine compound and its pharmaceutical...

C - Chemistry – Metallurgy – 07 – F

Patent

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Details

C07F 9/553 (2006.01) A61K 31/675 (2006.01)

Patent

CA 2633929

The present invention provides a benzoazepine compound represented by following general formula (1): or a salt thereof, wherein R represents a hydrogen atom, a hydroxy group optionally protected with a protecting group, etc., R1 represents a hydrogen atom or hydroxy-protecting group, and X represents an oxygen atom or a sulfur atom. The benzoazepine compound of the present invention and salts thereof have high solubility in water, and can be suitably used for injections. Image

La présente invention porte sur un composé de benzoazépine représenté par la formule générale suivante (1): ou un sel de celui-ci, caractérisé en ce que R représente un atome d'hydrogène, un groupe hydroxy protégé éventuellement par un groupe protecteur, entre autres, R<SUP>1</SUP> représente un atome d'hydrogène ou un groupe protecteur hydroxy, et X représente un atome d'oxygène ou un atome de soufre. Le composé de benzoazépine de la présente invention et les sels de celui-ci sont très solubles dans l'eau, et peuvent parfaitement s'utiliser pour les injections.

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